The supply chain design for perishable food with stochastic demand

© 2017 by the authors. It has been a challenging task to manage perishable food supply chains because of the perishable product's short lifetime, the possible spoilage of the product due to its deterioration nature, and the retail demand uncertainty. All of these factors can lead to a significant amount of shortage of food items and a substantial retail loss. The recent development of tracing and tracking technologies, which facilitate effective monitoring of the inventory level and product quality continuously, can greatly improve the performance of food supply chain and reduce spoilage waste. Motivated by this recent technological advancement, our research aims to investigate the joint decision of pricing strategy, shelf space allocation, and replenishment policy in a single-item food supply chain setting, where our goal is to maximize the retailer's total expected profit subject to stochastic retail demand. We prove the existence of optimality for the design of the perishable food supply chain. We then extend the single-item supply chain problem to a multi-item setting and propose an easy-to-implement searching algorithm to produce the optimal allocation of shelf space among these items for practical implementation. Finally, we provide numerical examples to demonstrate the effectiveness of our solution.Link_to_subscribed_fulltex

Supply chain cooperation with price-sensitive demand and environmental impacts

© 2016 by the authors. In this paper, we consider a two-echelon sustainable supply chain with price-sensitive demand. The government taxes the carbon footprint of each item caused by producing, transporting, and consuming the products. Both the supplier and retailer can exert efforts to reduce the carbon footprint. In a non-cooperative setting, the government only taxes the supplier, so that the retailer has no incentive to exert any effort to reduce the carbon footprint and the supplier merely decides on the selling price to maximize its own profit. We develop a centralized supply chain and show that there is an optimal solution to maximize the channel profit. Since the centralized policy may not be always not practical, we propose a tax-sharing contract, where both parties profit from the carbon footprint reduction. This problem is modeled as the Stackelberg game and Nash game. The results show that the leader has more power than the follower, which results in more profit. The Stackelberg game provides boundaries for both parties' profits in the Nash game. Although the tax-sharing contract does not result in full cooperation, its efficiency is still much higher than that of the non-cooperative case. The results are illustrated with some numerical experiments.Link_to_subscribed_fulltex

Probing Primordial Gravitational Waves: Ali CMB Polarization Telescope

In this paper, we will give a general introduction to the project of Ali CMB Polarization Telescope (AliCPT), which is a Sino-US joint project led by the Institute of High Energy Physics (IHEP) and has involved many different institutes in China. It is the first ground-based Cosmic Microwave Background (CMB) polarization experiment in China and an integral part of China's Gravitational Waves Program. The main scientific goal of AliCPT project is to probe the primordial gravitational waves (PGWs) originated from the very early Universe. The AliCPT project includes two stages. The first stage referred to as AliCPT-1, is to build a telescope in the Ali region of Tibet with an altitude of 5,250 meters. Once completed, it will be the worldwide highest ground-based CMB observatory and open a new window for probing PGWs in northern hemisphere. AliCPT-1 telescope is designed to have about 7,000 TES detectors at 90GHz and 150GHz. The second stage is to have a more sensitive telescope (AliCPT-2) with the number of detectors more than 20,000. Our simulations show that AliCPT will improve the current constraint on the tensor-to-scalar ratio $r$ by one order of magnitude with 3 years' observation. Besides the PGWs, the AliCPT will also enable a precise measurement on the CMB rotation angle and provide a precise test on the CPT symmetry. We show 3 years' observation will improve the current limit by two order of magnitude.Comment: 11 pages, 7 figures, 2 table

Data Visualization on Global Trends on Cancer Incidence An Application of IBM Watson Analytics

Visual analytics is widely used to explore data patterns and trends. This work leverages cancer data collected by World Health Organization (WHO) across over a hundred of cancer registries worldwide. In this study, we present a visual analytics platform, IBM Watson Analytics, to explore the patterns of global cancer incidence. We included 26 cancers from different geographic regions. An interactive interface was applied to plot a choropleth map to show global cancer distribution, and line charts to demonstrate historical cancer trends over 29 years. Subgroup analyses were conducted for different age groups. With real-time interactive features, we can easily explore the data with a selection of any cancer type, gender, age group, or geographical region. This platform is running on the cloud, so it can handle data in huge volumes, and is assessable by any computer connected to the Internet

Colorectal Cancer with Multiple Metastases: Is Palliative Surgery Needed?

In patients with symptomatic incurable metastatic colorectal cancer (mCRC), the goal of resection of the primary lesion is to palliate cancer-related morbidity, including obstruction, bleeding, or perforation. In patients with asymptomatic primary tumors and incurable metastatic disease, however, the necessity of primary tumor resection is less clear. Although several retrospective analyses suggest survival benefit in patients who undergo resection of the primary tumor, applying this older evidence to modern patients is out of date for several reasons. Modern chemotherapy regimens incorporating the novel cytotoxic agents oxaliplatin and irinotecan, as well as the target agents bevacizumab and cetuximab, have improved median survival from less than 1 year with the only available single-agent 5-fluorouracil until the mid-1990s to over 2 years. In addition to significant prolongation of overall survival, combinations of novel chemotherapeutic and target agents have allowed improved local and distant tumor control, decreasing the likelihood of local tumor-related complications requiring surgical resection. Resection of an asymptomatic primary tumor risks surgical complications and may postpone the administration of chemotherapy that may offer both systemic and local control. In conclusion, the morbidity and the mortality of unnecessary surgery or surgery that does not improve quality of life or survival in patients with mCRC of a limited life expectancy should be carefully evaluated. With the availability of effective combinations of chemotherapy and target agents, systemic therapy for the treatment of life-threatening metastases would be a preferable treatment strategy for unresectable asymptomatic patients with mCRC

Forecasts of CMB lensing reconstruction of AliCPT-1 from the foreground cleaned polarization data

Cosmic microwave background radiation (CMB) observations are unavoidably contaminated by emission from various extra-galactic foregrounds, which must be removed to obtain reliable measurements of the cosmological signal. In this paper, we demonstrate CMB lensing reconstruction in AliCPT-1 after foreground removal, combine the two bands of AliCPT-1 (90 and 150~GHz) with Planck HFI bands (100, 143, 217 and 353~GHz) and with the WMAP-K band (23~GHz). In order to balance contamination by instrumental noise and foreground residual bias, we adopt the Needlet Internal Linear Combination (NILC) method to clean the E-map and the constrained Internal Linear Combination (cILC) method to clean the B-map. The latter utilizes additional constraints on average frequency scaling of the dust and synchrotron to remove foregrounds at the expense of somewhat noisier maps. Assuming 4 modules observing 1 season from simulation data, the resulting effective residual noise in E- and B-map are roughly $15~\mu{\rm K}\cdot{\rm arcmin}$ and $25~\mu{\rm K}\cdot{\rm arcmin}$, respectively. As a result, the CMB lensing reconstruction signal-to-noise ratio (SNR) from polarization data is about SNR$\,\approx\,$4.5. This lensing reconstruction capability is comparable to that of other stage-III small aperture millimeter CMB telescopes.Comment: 12 pages, 6 figure

Operational Research: Methods and Applications

Throughout its history, Operational Research has evolved to include a variety of methods, models and algorithms that have been applied to a diverse and wide range of contexts. This encyclopedic article consists of two main sections: methods and applications. The first aims to summarise the up-to-date knowledge and provide an overview of the state-of-the-art methods and key developments in the various subdomains of the field. The second offers a wide-ranging list of areas where Operational Research has been applied. The article is meant to be read in a nonlinear fashion. It should be used as a point of reference or first-port-of-call for a diverse pool of readers: academics, researchers, students, and practitioners. The entries within the methods and applications sections are presented in alphabetical order

Operational Research: Methods and Applications

Throughout its history, Operational Research has evolved to include a variety of methods, models and algorithms that have been applied to a diverse and wide range of contexts. This encyclopedic article consists of two main sections: methods and applications. The first aims to summarise the up-to-date knowledge and provide an overview of the state-of-the-art methods and key developments in the various subdomains of the field. The second offers a wide-ranging list of areas where Operational Research has been applied. The article is meant to be read in a nonlinear fashion. It should be used as a point of reference or first-port-of-call for a diverse pool of readers: academics, researchers, students, and practitioners. The entries within the methods and applications sections are presented in alphabetical order. The authors dedicate this paper to the 2023 Turkey/Syria earthquake victims. We sincerely hope that advances in OR will play a role towards minimising the pain and suffering caused by this and future catastrophes